Journal
HUMAN IMMUNOLOGY
Volume 70, Issue 5, Pages 294-299Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2009.02.007
Keywords
FOXP3; Tregs; Tolerance; Autoimmunity; Dendritic cells; LRRC32; GARP; TGFbeta; Latency associated peptide
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FOXP3(+) regulatory T cells, a unique subset of T cells, are critical for orchestrating an immune response and preventing Self-reactivity. With) the increasing prevalence and unsatisfactory treatment of autoimmunity, allergic diseases, cancer and chronic infections, much attention has been focused on understanding their mechanisms of action in order to manipulate their function. One goal is to develop drugs or biologics that can enhance or abrogate their functions. Another approach is to utilize Tregs in adoptive cell-based therapy to treat autoimmune diseases or transplant-related complications. This review will focus on their therapeutic potential and mechanisms of action, particularly their interaction with dendritic cells. Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics.
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