Journal
HUMAN IMMUNOLOGY
Volume 69, Issue 11, Pages 776-780Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2008.08.287
Keywords
T suppressor cells; CTL; Peptide epitope; Dendritic cells
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We explored the possibility that antigen-specific human CD8(+) T cells, which display cytotoxic or suppressor function, can recognize the same peptide epitope. Using the human leukocyte antigen-A0201 restricted immunodominant cytomegalovirus epitope pp65-NLVPMVATV for pulsing either mature/immunogenic or ILT3(high)ILT4(high) tolerogenic dendritic cells (DC), we generated cytotoxic and suppressor CD8(+) T-cell lines, respectively. Our data indicate that modulating the functional state of DC is crucial to the development of tolerogenic or immunogeneic peptide-specific vaccines. (c) 2008 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
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