Journal
HUMAN IMMUNOLOGY
Volume 69, Issue 7, Pages 421-425Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2008.05.004
Keywords
T cells; TCR; PBMC; HIF-1; hypoxia-inducible factor
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Funding
- NCI NIH HHS [R01 CA112561, R01 CA112561-04] Funding Source: Medline
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Hypoxia-inducible factor-1 alpha (HIF-1 alpha) is critical not only in the regulation of oxygen homeostasis but also in the regulation of innate and adaptive immune systems. We previously reported that T-cell receptor-mediated activation of T cells in mice leads to the expression of an. alternative isoform of HIF-1 alpha that inhibits activated T cells in a delayed negative feed-back manner. In this paper, we describe a novel mRNA isoform of human HIF-1 alpha that is upregulated in peripheral T lymphocytes after T-cell receptor stimulation. This activation-inducible isoform is expressed using the alternative first exon I.3, and it encodes a protein that is 24 amino acids Longer than the ubiquitous HIF-1 alpha isoform. This mRNA isoform I.3 of HIF-1 alpha is expressed in a tissue-specific manner with the highest expression found in peripheral blood leukocytes and the thymus. (C) 2008 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
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