Journal
HUMAN GENETICS
Volume 127, Issue 4, Pages 455-458Publisher
SPRINGER
DOI: 10.1007/s00439-010-0798-3
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Funding
- Genoma Espana (Proyecto Piloto CeGen), Direccion General de Investigacion, Ministerio de Ciencia y Tecnologia, Spain [SAF2007-63171, BFU2007-63657]
- Direccio General de Recerca, Generalitat de Catalunya [2005SGR00608]
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Basques are a cultural isolate, and, according to mainly allele frequencies of classical polymorphisms, also a genetic isolate. We investigated the differentiation of Spanish Basques from the rest of Iberian populations by means of a dense, genome-wide SNP array. We found that F (ST) distances between Spanish Basques and other populations were similar to those between pairs of non-Basque populations. The same result is found in a PCA of individuals, showing a general distinction between Iberians and other South Europeans independently of being Basques. Pathogen-mediated natural selection may be responsible for the high differentiation previously reported for Basques at very specific genes such as ABO, RH, and HLA. Thus, Basques cannot be considered a genetic outlier under a general genome scope and interpretations on their origin may have to be revised.
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