Journal
HUMAN GENETICS
Volume 123, Issue 6, Pages 665-667Publisher
SPRINGER
DOI: 10.1007/s00439-008-0519-3
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Funding
- NHLBI NIH HHS [R01 HL064822, R01 HL071225-05, HL064822, HL071225, R01 HL071225, HL55502, R01 HL055502] Funding Source: Medline
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ATP-sensitive K(+) (K(ATP)) channel mutations have been identified in individuals with dilated cardiomyopathy and overt heart failure. Here, a common E23K functional polymorphism in the Kir6.2 channel pore versus cardiac phenotype was studied in a cross-sectional community-based cohort (n = 2,031). The KK genotype was associated with greater left ventricular size among subjects with increased stress load due to hypertension. These findings implicate Kir6.2 K23 as a risk factor for adverse subclinical myocardial remodeling, and underscore the significance of cardiac K(ATP) channels within the population.
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