Journal
HUMAN BRAIN MAPPING
Volume 39, Issue 12, Pages 5126-5144Publisher
WILEY
DOI: 10.1002/hbm.24314
Keywords
attenuation correction; dynamic FDG-PET; functional MRI; joint image reconstruction; motion; MR-PET; PET/MR
Funding
- Reignwood Cultural Foundation
- ARC Discovery Early Career Research Award [DE150100406]
- ARC Centre of Excellence for Integrative Brain Function [CE140100007]
- Australian Research Council [LP170100494]
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Simultaneous Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) scanning is a recent major development in biomedical imaging. The full integration of the PET detector ring and electronics within the MR system has been a technologically challenging design to develop but provides capacity for simultaneous imaging and the potential for new diagnostic and research capability. This article reviews state-of-the-art MR-PET hardware and software, and discusses future developments focusing on neuroimaging methodologies for MR-PET scanning. We particularly focus on the methodologies that lead to an improved synergy between MRI and PET, including optimal data acquisition, PET attenuation and motion correction, and joint image reconstruction and processing methods based on the underlying complementary and mutual information. We further review the current and potential future applications of simultaneous MR-PET in both systems neuroscience and clinical neuroimaging research. We demonstrate a simultaneous data acquisition protocol to highlight new applications of MR-PET neuroimaging research studies.
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