Journal
LARYNGOSCOPE
Volume 126, Issue 2, Pages E68-E73Publisher
WILEY
DOI: 10.1002/lary.25649
Keywords
Curcumin; oral ulcer; wound healing; mucosa
Funding
- Korea Health Technology Research and Development Project through the Korea Health Industry Development Institute
- Ministry of Health and Welfare, Republic of Korea [HI14C1541]
Ask authors/readers for more resources
Objectives/HypothesisOral ulcers are very common and can compromise the quality of life of patients with pain. The objective of this study was to evaluate mucosal healing with curcumin in an animal oral ulcer model. Study DesignExperimental study. MethodsTwenty New Zealand white rabbits were used. Round filter paper 6 mm in diameter was soaked with 15 l 50% acetic acid and applied over the upper labial gingiva, creating a uniform circular ulcer. After creation of an oral ulcer, curcumin, the active substance in tumeric, was applied twice over the ulcer in the experimental group but not in the control group. The ulcer area was calculated by maximal (D) and minimal (d) diameter : x D x d/4. All animals were weighed, and the area was measured on days 0, 7, and 14. On days 7 and 14, half of the animals were sacrificed and gingival specimens were acquired. ResultsCurcumin treatment exhibited accelerated healing such that the gross appearance of the ulcer demonstrated a recognizable difference in wound healing between the curcumin-treated and control groups with time. Weight loss was observed after the creation of oral ulcer in the control group. However, the curcumin-treated group gained weight with time, resulting in a significant weight difference. On day 14, epithelial regeneration was completed in the treated group but incomplete in the control group. ConclusionTopical application of curcumin enhanced the wound-healing process of oral ulcer in the animal model, which implicate that curcumin can be used as an effective and safe medical tool in the treatment of oral ulcer. Level of EvidenceNA. Laryngoscope, 126:E68-E73, 2016
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available