Journal
HUMAN BRAIN MAPPING
Volume 30, Issue 7, Pages 2220-2231Publisher
WILEY
DOI: 10.1002/hbm.20663
Keywords
resting state functional MRI; complex network; modularity; small world
Funding
- Dutch Scientific Organization (ZON-MW) [10-0001002]
- VU University Medical Center
- GGZ Buitenamstel
- GGZ Geestgronden
- Leiden University Medical Center
- GGZ Rivierduinen
- University Medical Center Groningen, Lentis
- GGZ Friesland
- GGZ Drenthe
Ask authors/readers for more resources
Functional magnetic resonance imaging (fMRI) studies have shown that anatomically distinct brain regions are functionally connected during the resting state. Basic topological properties in the brain functional connectivity (BFC) map have highlighted the BFC's small-world topology. Modularity, a more advanced topological property, has been hypothesized to be evolutionary advantageous, contributing to adaptive aspects of anatomical and functional brain connectivity. However, current definitions of modularity for complex networks focus on nonoverlapping clusters, and are seriously limited by disregarding inclusive relationships. Therefore, BFC's modularity has been mainly qualitatively investigated. Here, we introduce a new definition of modularity, based on a recently improved clustering measurement, which overcomes limitations of previous definitions, and apply it to the study of BFC in resting state fMRI of 53 healthy subjects. Results show hierarchical functional modularity in the brain. Hum Brain Mapp 30:2220-2231, 2009. (C) 2008 Wiley-Liss, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available