Journal
HUMAN BRAIN MAPPING
Volume 30, Issue 10, Pages 3200-3208Publisher
WILEY
DOI: 10.1002/hbm.20741
Keywords
working memory; prenatal alcohol exposure; development; fMRI
Funding
- NIH NIAAA NRSA [F31AA16039]
- NIH NIDA [R21 DA15878, RO1 DA017831]
- NIH NIAAA [U24AA014808, U01AA014834]
- NIH NTCRR [U54 RR021813, 5FY03-12]
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This study evaluated the neural basis of verbal working memory (WM) function in a group of 20 children and adolescents with fetal alcohol spectrum disorders (FASDs) and 20 typically developing comparison participants using functional magnetic resonance imaging (IMRI). Both groups showed prominent activation in the frontal-parietal-cerebellar network known to be important for verbal WM. Despite equivalent behavioral performance between groups, alcohol-exposed individuals showed increased activation relative to typically developing individuals in left dorsal frontal and left inferior parietal cortices, and bilateral posterior temporal regions during verbal WM. These effects remained even when group differences on IQ were statistically controlled. This pattern of increased activation coupled with equivalent behavioral performance between groups suggests that individuals with FASD recruit a more extensive network of brain regions during verbal WM relative to typically developing individuals. These findings may suggest that frontal-parietal processing during verbal WM is less efficient in alcohol-exposed individuals. Hum Brain Mapp 30:3200-3208, 2009, (C) 2009 Wiley-Liss, Inc.
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