Journal
HUMAN AND ECOLOGICAL RISK ASSESSMENT
Volume 15, Issue 1, Pages 121-137Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10807030802615659
Keywords
seabass; benzo(a)pyrene; biomarkers; growth; swimming velocity; food intake; oxidative stress
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Funding
- Fundacao para a Ciencia e a Tecnologia (FCT) of Portugal [POCTI/BPD/21070/2004, PDTC/MAR/64074/2006]
- EU
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The main purpose of this study was to investigate the effects of benzo( a) pyrene (BaP) on seabass (Dicentrarchus labrax) juveniles using parameters at different levels of biological organization. Liver antioxidant status, BaP biotransformation and accumulation, growth, and behavior were determined in juveniles after 28 d exposure to BaP (1-16 mu g/l). Liver ethoxyresorufin O-deethylase increased in seabass exposed to 1-8 mu g/l of BaP. Liver glutathione S-transferases and catalase activities were significantly increased at 4 and 8 mu g/l, but a slight decrease was observed at the highest concentrations tested. Bile BaP metabolites were significantly different from the control group at 1 and 16 mu g/l BaP. Liver BaP metabolites and lipid peroxidation significantly increased at 8 and 16 mu g/l BaP. These results suggest that BaP metabolites' accumulation induces oxidative damage in seabass liver. Body weight and length increase were significantly reduced in fish exposed to BaP, with LOECs of 16 and 4 mu g/l, respectively. Food intake and swimming velocity were significantly decreased after exposure to BaP, with LOEC values of 16 and 8 mu g/l, respectively. Results suggest that at concentrations of BaP equal or higher than 8 mu g/l, the detoxification capacity decreases, an accumulation of liver BaP metabolites occurs causing lipid peroxidation, affecting growth and swimming capability of fish.
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