Journal
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
Volume 11, Issue 3, Pages 325-332Publisher
SPRINGER INTERNATIONAL PUBLISHING AG
DOI: 10.14310/horm.2002.1361
Keywords
Age; Bone; Menopause; Muscle; Strength
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OBJECTIVE: The aim of this work was to examine the effects of age and menopause on muscle strength and on the muscle-bone interaction. DESIGN: One hundred ninety-four healthy women (mean age 49.8 +/- 12.6 SD years) were assessed. Maximal Voluntary Contraction (MVC, Newton, N) by Hand Grip Dynamometer, bone mineral density at one third of the radius (R-BMD) by dual-energy X-ray absorptiometry (DXA) and phalangeal ultrasound by the DBM Sonic 1200 device were evaluated at the upper dominant limb. Ultrasonometric parameters considered were Amplitude-Dependent Speed of Sound (ADSoS) and Ultrasound Bone Profile Index (UBPI). RESULTS: MVC significantly decreased with age (r(2) = -0.12, p < 0.005). For each level of age, fertile women had a greater MVC compared to postmenopausal women (r(2) = 0.015, p < 0.005). In the whole sample, a statistically significant correlation between MVC and R-BMD (r = 0.354, p < 0.001) and between MVC and ADSoS (r = 0.294) and UBPI (r = 0.311)(p < 0.001 for both) were observed. CONCLUSIONS: We conclude that age and menopausal status significantly contributed to the reduction of muscle strength. The decline of muscular strength significantly correlated with quantitative and qualitative bone features.
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