Journal
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
Volume 7, Issue 4, Pages 325-329Publisher
SPRINGER INTERNATIONAL PUBLISHING AG
DOI: 10.14310/horm.2002.1214
Keywords
Anticoagulants; Coagulation; Diabetes mellitus; Metformin overdose
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It is widely known that metformin reduces the levels of circulating pro-coagulant factors and improve fibrinolytic activity in type 2 diabetes when used in therapeutic doses. Potential alterations of coagulation have not been reported in patients with metformin intoxication. We evaluated certain components of the coagulation system in a patient with metformin intoxication upon admission and after recovery. Our results indicate that both the levels of coagulation proteins synthesized by the liver and the anti-coagulant activity decrease temporarily in metformin intoxication. Nevertheless, no change in the coagulation factors secreted by the endothelium were observed.
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