Journal
HORMONES AND BEHAVIOR
Volume 58, Issue 5, Pages 786-791Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yhbeh.2010.07.014
Keywords
Anxiety; Depression; Elevated plus-maze test; Forced swim test; Hippocampus; Neurogenesis; Ovarian hormones; Ovariectomy; Stress
Categories
Funding
- Ministerio de Ciencia e Innovacion, Spain [BFU2008-02950-C03-01/02]
- CONACYT [206069]
- SEP
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Ovarian hormones exert anti-depressive and anxiolytic actions. In this study we have analyzed the effects of ovariectomy on the development of anxiety and depression-like behaviors and on cell proliferation in the hippocampus of mice submitted to chronic unpredictable stress. Animals submitted to stress 4 months after ovariectomy showed a significant increase in immobility behavior in the forced swimming test compared to animals submitted to stress 2 weeks after ovariectomy. In addition, long-term ovariectomy resulted in a significant decrease on the time spent in the open arms in the elevated plus-maze test compared to control animals. Stress did not significantly affect cell proliferation in the hilus of the dentate gyrus. However, ovariectomy resulted in a significant decrease in cell proliferation. These results indicate that long-term deprivation of ovarian hormones enhances the effect of chronic unpredictable stress on depressive- and anxiety-like behaviors in mice. Therefore, a prolonged deprivation of ovarian hormones may represent a risk factor for the development of depressive and anxiety symptoms after the exposure to stressful experiences. (C) 2010 Elsevier Inc. All rights reserved.
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