Journal
HORMONES AND BEHAVIOR
Volume 56, Issue 3, Pages 309-314Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yhbeh.2009.06.008
Keywords
GPR30; Estradiol; G-1; PPT; DPN; T-maze; Working memory
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Funding
- NIH [R01 AG021471]
- Eunice Kennedy Shriver NICHD/NIH (SCCRIR) [U54-HD28934]
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Previous work has shown that continuous estradiol replacement in young ovariectomized rats enhances acquisition of a delayed matching-to-position (DMP) T-maze task over that of ovariectomized controls. The mechanism by which estradiol confers this benefit has not been fully elucidated. This study examined the role of selective estrogen receptor agonists of ER alpha, ER beta, and GPR30 in the enhancement of spatial learning on a DMP task by comparing continuous estradiol replacement with continuous administration of PPT (an agonist of ER alpha), DPN (an agonist of ER beta), or G-1 (an agonist of GPR30) relative to gonadally intact and ovariectomized vehicle-treated controls. It was found that ovariectomy impaired acquisition on this task, whereas all ER selective agonists restored the rate of acquisition to that of gonadally intact controls. These data suggest that estradiol can work through any of several estrogen receptors to enhance the rate of acquisition on this task. (C) 2009 Elsevier Inc. All rights reserved.
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