Journal
HORMONES AND BEHAVIOR
Volume 53, Issue 5, Pages 706-715Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yhbeh.2008.02.012
Keywords
androgen receptor; apoE4; testosterone; tfm
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Funding
- NCRR NIH HHS [M01 RR000334, 5 M01 RR000334] Funding Source: Medline
- NIA NIH HHS [R01 AG020904-04, P30 AG08017, R01 AG020904-03, P30 AG008017, R01 AG020904-04S1, R01 AG020904-02, R01 AG020904-04S2, R01 AG020904] Funding Source: Medline
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Reduced androgen levels in aged men and women might be risk factors for age-related cognitive decline and Alzheimer's disease (AD). Ongoing clinical trials are designed to evaluate the potential benefit of estrogen in women and of testosterone in men. In this review, we discuss the potential beneficial effects of androgens and androgen receptors (ARs) in males and females. In addition, we discuss the hypothesis that AR interacts with apolipoprotein (apoE)4, encoded by epsilon 4 and a risk factor for age-related cognitive decline and AD, and the potential consequences of this interaction. (c) 2008 Elsevier Inc. All rights reserved.
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