Journal
HORMONE RESEARCH IN PAEDIATRICS
Volume 76, Issue 6, Pages 379-385Publisher
KARGER
DOI: 10.1159/000331462
Keywords
Blood pressure; Insulin sensitivity; Adiponectin; Obesity; Adolescents; Adipose tissue
Categories
Funding
- United States Public Health Service [RO1 HD27503, K24 HD01357]
- Richard L. Day Endowed Chair
- Department of Defense
- ADA
- GCRC [MO1 RR00084]
- CTSA [UL1 RR024153]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [K24HD001357, R01HD027503] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [UL1RR024153, M01RR000084] Funding Source: NIH RePORTER
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Aims: To examine the cross-sectional relationship between blood pressure (BP) and (1) in vivo insulin sensitivity (IS) and (2) circulating adiponectin levels in overweight adolescents, and to determine if these relationships are driven by adiposity. Methods: Sixty-five white pubertal overweight adolescents underwent a hyperinsulinemic-euglycemic clamp to measure IS. Body composition and abdominal adiposity were determined by dual energy X-ray absorptiometry and computed tomography scan. BP was measured by an automated sphygmomanometer every 10 min over 1 h, between 06:00 and 07:00 a.m. Results: In vivo IS was not associated with BP after adjustment for adiposity measurements (body mass index, percentage body fat or abdominal adiposity). However, adiponectin was inversely related to systolic BP independent of adiposity. Conclusion: Our findings demonstrate that in overweight adolescents the relationship between in vivo IS and systolic BP is mediated through adiposity. However, the association between adiponectin and BP is independent of adiposity suggestive of a potential modulatory role of adiponectin in BP regulation. Copyright (C) 2011 S. Karger AG, Basel
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