Journal
HORMONE AND METABOLIC RESEARCH
Volume 44, Issue 1, Pages 15-20Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1297990
Keywords
visceral fat; 11 beta-hydroxysteroid dehydrogenase type 1; glucocorticoid; morphology; adipogenesis
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Funding
- Japanese Ministry of Health, Labour and Welfare
- National Institute of Diabetes and Digestive and Kidney Disease [SC1DK087655]
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Glucocorticoid (GC) excess promotes adipose tissue accumulation, and 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) plays an important role in the local amplification of GC. Therefore, in this study, we investigated the effects of carbenoxolone (CBX), an 11 beta-HSD1 inhibitor, on morphological changes in visceral fat, and the expression of genes involved in adipogenesis and lipid metabolism in high-fat (HF) diet-fed mice. Mice were fed a HF diet from 5 weeks of age. At 10 weeks of age, the mice received an intraperitoneal injection of CBX or vehicle every day for 2 weeks. CBX decreased body weight and visceral fat mass, and improved insulin sensitivity in HF-fed mice. This was accompanied by reduced adipocyte size and a decrease in large-sized adipocytes in visceral fat. The expression of adipogenesis (PPAR. and C/EBPa), glucose transport (GLUT4) and lipid metabolism (LPL, ATGL, and HSL)-related genes were suppressed in CBX mice. CBX treatment induced beneficial morphological changes in visceral fat and decreased the expression of adipogenesis, glucose transport and lipid metabolism-related genes. These findings reveal a potential mechanism underling the effects of CBX on reduced fat accumulation and improved insulin sensitivity.
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