Journal
HORMONE AND METABOLIC RESEARCH
Volume 41, Issue 8, Pages 626-629Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1216359
Keywords
adipokines; follow-up studies; haemoglobin A; glycosylated; C-reactive protein
Categories
Funding
- Medical Research Council
- Wingate Foundation
- Economic and Social Research Council
- British Heart Foundation
- Health and Safety Executive
- Department of Health
- National Heart Lung and Blood Institute [HL36310]
- NIH: National Institute on Aging [AG13196]
- NIH
- Agency for Health Care Policy Research [HS06516]
- John D and Catherine T. MacArthur Foundation
- MRC [G0501184] Funding Source: UKRI
- British Heart Foundation [RG/07/008/23674] Funding Source: researchfish
- Medical Research Council [G0100222, G0501184, G8802774, G19/35] Funding Source: researchfish
Ask authors/readers for more resources
Our aim of the present work was to study the effect of serum adiponectin on incident diabetes and HbA1c values. We measured baseline serum adiponectin levels in a nested case-control selection (n = 140) of the Whitehall 11 Cohort. Participants (mean [SD] age 50.9 [6.3] years) had no prevalent diabetes or CHD at baseline. Cases (n=55) had incident diabetes according to an oral glucose tolerance test during follow-up (mean: 11.5 +/- 3.0 years). Adiponectin levels were lower among cases (9.3 mu g/ml, 3.2 [median; IQR] vs. 10.5; 3.6, p=0.01). The risk of incident diabetes decreased by 11% (p=0.03) for 1 mu g/ml higher adiponectin levels. Higher adiponectin levels were associated with lower HbA1c at follow-up (p<0.05). Both associations were stable to adjustment for age, sex, body mass index, systolic blood pressure, and serum lipids, and for the case of HbA1c, also for C-reactive protein (all p<0.05). The observed robust, prospective associations support that adiponectin is an independent predictor of diabetes and the degree of glycaemic impairment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available