3.9 Article

Rates of HCV Treatment Eligibility Among HCV-Monoinfected and HCV/HIV-Coinfected Patients in Tertiary Care Referral Centers

Journal

HIV CLINICAL TRIALS
Volume 10, Issue 1, Pages 25-32

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1310/hct1001-25

Keywords

coinfection; comorbidities; contraindications; HCV; HIV; treatment eligibility

Funding

  1. National Institutes of Health/National Institute on Drug Abuse [DA016175-01A1]
  2. National Institute for Allergy and Infectious Diseases [K01 AI070001-A1]
  3. National Center for Complementary and Alternative Medicine award [K24 AT001676]

Ask authors/readers for more resources

Background: Treatment eligibility rates in patients with HCV monoinfection have not been directly compared with patients with HCV/HIV coinfection. These data are important for planning interventions to optimize HCV management. Method: We enrolled consecutive HCV-monoinfected and HCV/HIV-coinfected subjects presenting to hepatology and HIV clinics at three academic medical centers. Data were obtained through structured subject and provider interviews and a review of medical records. Results: Of the 399 subjects enrolled, 241 (60%) were HCV monoinfected and 158 (40%) were HCV/HIV coinfected. HCV/HIV-coinfected subjects were less likely to have indications for treatment based on HCV RNA positivity (70.9% vs. 81.3%, p=.04) but were more likely to have at least one contraindication to treatment (81.6% vs. 64.9%, p<.004). Depression and ongoing alcohol and injection drug abuse were more common in the HCV/HIV-coinfected persons. HCV/HIV-coinfected persons were less likely to undergo liver biopsy or to ever get treatment for HCV. Conclusions: HCV/HIV-coinfected persons are less likely to undergo a liver biopsy or be eligible for HCV therapy and are more likely to have treatment contraindications compared with HCV-monoinfected subjects. Strategies to address modifiable factors (e.g., depression, substance abuse) may enhance treatment eligibility in HCV-infected populations.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

3.9
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available