Journal
HISTOPATHOLOGY
Volume 62, Issue 4, Pages 642-650Publisher
WILEY-BLACKWELL
DOI: 10.1111/his.12059
Keywords
angiomyolipoma; cathepsin K; immunohistochemistry; PEComa; tuberous sclerosis
Categories
Funding
- National Natural Science Foundation of China [81101933]
- Natural Science Foundation of Jiangsu Province, China [BK2010463]
- Maixin fund [m1009]
- Austrian Science Fund (FWF) [M1009] Funding Source: Austrian Science Fund (FWF)
Ask authors/readers for more resources
Aims Recent studies have demonstrated that cathepsin K seems to be a powerful marker in identifying renal perivascular epithelioid cell neoplasms (PEComas). However, the expression in extrarenal PEComas has not been well characterized due to their rare incidence. Our aim was to investigate the expression of cathepsin K in a wide spectrum of extrar-enal PEComas and evaluate its potential diagnostic usefulness in comparison with other commonly used markers. Methods and results Twenty-three cases of PEComa (liver, n=9; lung, n=1; broad ligament of uterus, n=1; vertex subcutaneous soft tissue, n=1; abdominal wall, n=1; and kidney, n=10) were selected for study. All displayed a high percentage of cells with moderately to strongly positive reactions for cathepsin K (mean 91%; range 80100%). HMB45, Melan-A and smooth muscle actin (SMA) were expressed in 78, 87 and 87% of cases, respectively, with various percentages of positive cells (mean, 34, 40 and 38%; range 080, 090 and 090%). Transcription factor E3 (TFE3) was expressed strongly in only three cases; none exhibited evidence of TFE3 gene fusion or amplification. Conclusions Cathepsin K appears to be more powerful than other commonly used markers in diagnosing a wide spectrum of PEComas and distinguishing them from the majority of human cancers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available