Journal
HISTOPATHOLOGY
Volume 62, Issue 1, Pages 111-123Publisher
WILEY
DOI: 10.1111/his.12053
Keywords
apoptosis; beta-catenin; chromosomal instability; E-cadherin; endometrial carcinoma; K-RAS; microsatellite instability; molecular genetics; PTEN; PIK3CA; TP53
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Funding
- Fundacion Mutua Madrilena [AP75732010, 2009SGR794]
- RTICC [RD06/0020/1034, RD06/0020/0015]
- Fundacion Asociacion Espanola contra el Cancer
- programa de intensificacion de la investigacion, Instituto Carlos III, Department of Health, Spain
- [FIS PI100922]
- [FIS PI11-01561]
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Matias-Guiu X, & Prat J (2013) Histopathology 62, 111-123 Molecular pathology of endometrial carcinoma This review paper discusses the main molecular alterations of endometrial carcinoma, the most common cancer of the female genital tract. Two clinicopathological variants are recognized: the oestrogen-related (type I, endometrioid carcinoma) and the non-oestrogen-related (type II, non-endometrioid carcinoma). Whereas type I shows microsatellite instability and mutations in PTEN, PIK3CA, K-RAS and CTNNB1 (beta-catenin), type II exhibits TP53 mutations and chromosomal instability. Recent investigations regarding the role of non-coding RNA have provided important information regarding tumour progression. Understanding pathogenesis at the molecular level is essential for identifying biomarkers of potential use in targeted therapies.
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