Journal
HISTOPATHOLOGY
Volume 61, Issue 6, Pages 1183-1197Publisher
WILEY
DOI: 10.1111/j.1365-2559.2012.04339.x
Keywords
elderly; Epstein-Barr virus; human immunodeficiency virus (HIV)-negative; lymphoid malignancy; plasmablastic lymphoma
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [24590411]
- Grants-in-Aid for Scientific Research [22591045, 24590411] Funding Source: KAKEN
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Liu F, Asano N, Tatematsu A, Oyama T, Kitamura K, Suzuki K, Yamamoto K, Sakamoto N, Taniwaki M, Kinoshita T & Nakamura S ?(2012) Histopathology?Plasmablastic lymphoma of the elderly: a clinicopathological comparison with age-related EpsteinBarr virus-associated B cell lymphoproliferative disorder Aims: Plasmablastic lymphoma (PBL) is an aggressive lymphoma with a terminally differentiated B cell phenotype; half of patients with this disease have EpsteinBarr virus (EBV) infection. The majority of PBL cases are associated with human immunodeficiency virus (HIV) infection, while the remaining HIV-negative cases were accompanied by other immunodeficiency conditions or immunosenescence in the elderly. Methods and results: To characterize HIV-negative PBL of the elderly (PBL-E), we compared the clinicopathological characteristics of 10 cases of PBL-E and 124 cases with age-related EBV-associated B cell lymphoproliferative disorder (AR-EBVLPD). The 10 PBL-E (eight men, two women; median age: 68 years) were associated with a more indolent clinical behaviour and a better overall survival than AR-EBVLPD. Extranodal involvement was higher in PBL-E (50%) than AR-EBVLPD; notably, the nasal cavity was affected most frequently in PBL-E (60%). Immunoglobulin heavy chain/(IGH)/MYC translocation was detected in half of the PBL-E cases. Conclusions: PBL-E shares some clinical features with AR-EBVLPD, such as HIV negativity, old age, and EBV infection, no known immunosuppressive condition but there are some differences such as a higher ratio of extranodal involvement and better prognosis. PBL-E is a newly recognized condition and should be distinguished from HIV-positive PBL, sharing features with AR-EBVLPD in particular, immunosenescence of the elderly.
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