Journal
HISTOPATHOLOGY
Volume 59, Issue 6, Pages 1046-1056Publisher
WILEY
DOI: 10.1111/j.1365-2559.2011.04043.x
Keywords
colorectal cancer; lymphocytic response; pseudo-cytoplasmic fragments; serrated adenocarcinoma; tumour budding; tumour growth pattern
Categories
Funding
- Instituto de Salud Carlos III
- Ministerio de Sanidad, Spain [P1081210]
- Academy of Finland [127990]
- Fundacion para la Formacion e Investigacion Sanitarias de la Consejeria de Sanidad de la Region de Murcia
- Academy of Finland (AKA) [127990, 127990] Funding Source: Academy of Finland (AKA)
Ask authors/readers for more resources
Aims: To assess the incidence of tumour budding (TB), cytoplasmic pseudo-fragments (CyPs), tumour growth pattern (TGP) and peritumoural lymphocytic infiltration (PLI) in a series of serrated adenocarcinoma (SAC) and conventional carcinomas (CCs) of the colorectum in order to ascertain whether such features could explain the worse prognosis of SAC and whether they have prognostic value in SACs. Methods and results: Tumour budding, CyPs, TGP and PLI were evaluated in 81 SACs and 81 matched CCs. Kaplan-Meier survival curves and Cox logistic regression analysis were obtained for histological parameters. SACs had more high-grade (HG) TB (HG-TB) (69.1%), HG-CyPs (47%), infiltrative TGP (42%) and weak PLI (W-PLI) (65.4%) than CCs (40.7%, P = 0.0003; 19.7%, P = 0.0002; 29.7%, P = 0.07; 45.7%, P = 0.0087). SACs with HG-TB (P = 0.017), HG-CyPs (P = 0.045), infiltrating TGP (P < 0.001) and W-PLI (P = 0.04) had a worse 5-year survival, as had SACs with infiltrating TGP (P = 0.047) and W-PLI (P = 0.04) compared with CCs. For SACs, infiltrative TGP and W-PLI were independent prognostic parameters on multivariate analysis, as was location and regional node status. Conclusion: Compared to CC, SAC displayed more HG-TB, HG-CyPs and fewer PLI at the invasive margins and this may account for its poorer clinical outcome. TB, CyPs, TGP and PLI are useful histological prognostic aids in SAC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available