Journal
HISTOCHEMISTRY AND CELL BIOLOGY
Volume 134, Issue 5, Pages 423-443Publisher
SPRINGER
DOI: 10.1007/s00418-010-0753-3
Keywords
Mass spectrometry; Chemical imaging; Molecular imaging; Biological surfaces; DESI; MALDI; SIMS
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Funding
- Ministry of Education, Youth, and Sports of the Czech Republic [LC545, ME10013]
- Institute of Microbiology, Academy of Sciences of the Czech Republic [AV0Z50200510]
- Czech Science Foundation [P206/10/P018]
- European Community
- Academy of Finland [1122354]
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This review describes the current state of mass spectrometry imaging (MSI) in life sciences. A brief overview of mass spectrometry principles is presented followed by a thorough introduction to the MSI workflows, principles and areas of application. Three major desorption-ionization techniques used in MSI, namely, secondary ion mass spectrometry (SIMS), matrix-assisted laser desorption ionization (MALDI), and desorption electrospray ionization (DESI) are described, and biomedical and life science imaging applications of each ionization technique are reviewed. A separate section is devoted to data handling and current challenges and future perspectives are briefly discussed at the end.
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