Journal
HIPPOCAMPUS
Volume 24, Issue 4, Pages 363-368Publisher
WILEY-BLACKWELL
DOI: 10.1002/hipo.22245
Keywords
epigenetics; DNA methylation; hippocampus; brain and neurodegeneration
Categories
Funding
- Cellex Foundation
- Botin Foundation
- Fundacio Agrupacio Mutua
- Health and Science Departments of the Catalan Government (Generalitat de Catalunya)
- ICREA Funding Source: Custom
Ask authors/readers for more resources
Genetic screening in Alzheimer's disease (AD) has identified only a handful of genes that are mutated in the disorder. Thus, for a very large proportion of patients, the biology of their disease is poorly understood. Epigenetic alterations may provide an explanation in these cases. Using DNA methylation profiles of human hippocampus from controls and patients, we have identified the presence of promoter hypermethylation of the dual-specificity phosphatase 22 (DUSP22) gene in AD. DUSP22 is a likely candidate gene for involvement in the pathogenesis of the disorder since, as we demonstrate here, it inhibits PKA activity and thereby determines TAU phosphorylation status and CREB signaling. (c) 2014 The Authors. Hippocampus Published by Wiley Periodicals, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available