Journal
HIPPOCAMPUS
Volume 24, Issue 2, Pages 131-134Publisher
WILEY-BLACKWELL
DOI: 10.1002/hipo.22227
Keywords
wheel running; sports; brain matter; aging; mice; hippocampus
Categories
Funding
- Deutsche Forschungsgemeinschaft [SFB636-B3]
- [SFB636-Z3]
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Recently, a larger hippocampus was found in exercising mice and men. Here we studied the morphological underpinnings in wheel running mice by longitudinal magnetic resonance imaging. Voxel-based morphometry revealed that running increases hippocampal volume by inhibiting an early age-related gray matter loss. Disruption of neurogenesis-related neuroplasticity by focalized irradiation is sufficient to block positive effects of exercise on macroscopic brain morphology. (c) 2013 Wiley Periodicals, Inc.
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