Journal
HIPPOCAMPUS
Volume 22, Issue 11, Pages 2095-2100Publisher
WILEY
DOI: 10.1002/hipo.22032
Keywords
adolescence; overweight; spatial learning; memory; neurogenesis
Categories
Funding
- AXA
- Emergence de Jeune Equipe INRA
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Increased consumption of high-fat diet (HFD) leads to obesity and adverse neurocognitive outcomes. Childhood and adolescence are important periods of brain maturation shaping cognitive function. These periods could consequently be particularly sensitive to the detrimental effects of HFD intake. In mice, juvenile and adulthood consumption of HFD induce similar morphometric and metabolic changes. However, only juvenile exposure to HFD abolishes relational memory flexibility, assessed after initial radial-maze concurrent spatial discrimination learning, and decreases neurogenesis. Our results identify a critical period of development covering adolescence with higher sensitivity to HFD-induced hippocampal dysfunction at both behavioral and cellular levels. (c) 2012 Wiley Periodicals, Inc.
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