Journal
HIPPOCAMPUS
Volume 19, Issue 10, Pages 973-980Publisher
WILEY
DOI: 10.1002/hipo.20631
Keywords
learning; DG; BDNF; exercise; perirhinal cortex
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Funding
- Irish Research Council for Science, Engineering and Technology (Embark Initiative)
- Health Research Board, Ireland
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Short periods of forced exercise have been reported to selectively induce enhancements in hippocampal-dependent cognitive function, possibly via brain-derived neurotrophic factor (BDNF)-mediated mechanisms. In this study, we report that 1 week of treadmill running significantly enhanced both object displacement (spatial) and object substitution (nonspatial) learning. These behavioral changes were accompanied by increased expression of BDNF protein in the dentate gyrus, hippocampus, and perirhinal cortex. The effects of exercise on object substitution were mimicked by intracerebroventricular injection of BDNF protein. These data are consistent with the hypothesis that exercise has the potential to enhance cognitive function in young healthy rats, possibly via a mechanism involving increased BDNF expression in specific brain regions. (C) 2009 Wiley-Liss, Inc.
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