Journal
HIPPOCAMPUS
Volume 18, Issue 10, Pages 985-988Publisher
WILEY
DOI: 10.1002/hipo.20468
Keywords
menstrual cycle; MRI; anatomy; VBM; estrogen; structural
Categories
Funding
- DeWitt Wallace Fund of the New York Community Trust
- David Clayson Memorial Fund
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH074808] Funding Source: NIH RePORTER
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Magnetic resonance imaging (MRI) in association with Jacobian-modulated voxel-based morphometry (VBM) was used to test for regional variation in gray matter over the menstrual cycle. T1-weighted anatomical images were acquired using a spoiled gradient recalled acquisition sequence in 21 women. Each subject was scanned twice: once during the postmenstrual late-follicular phase (Days 10-12 after onset of menses), and once during the premenstrual late-luteal phase (1-5 days before the onset of menses). Gray matter was relatively increased in the right anterior hippocampus and relatively decreased in the right dorsal basal ganglia (globus pallidus/putamen) in the postmenstrual phase. Verbal declarative memory was increased in the postmenstrual vs. premenstrual phase. This first report of human brain structural plasticity associated with the endogenous menstrual cycle extends well-established animal findings of hormone-mediated hippocampal plasticity to humans, and has implications for understanding alterations in cognition and behavior across the menstrual cycle. (C) 2008 Wiley-Liss, Inc.
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