4.3 Article

High-resolution multi-voxel pattern analysis of category selectivity in the medial temporal lobes

Journal

HIPPOCAMPUS
Volume 18, Issue 6, Pages 536-541

Publisher

WILEY
DOI: 10.1002/hipo.20433

Keywords

fMRI; parahippocampal; memory; encoding; perirhinal

Categories

Funding

  1. NATIONAL INSTITUTE OF MENTAL HEALTH [F32MH079621, R01MH068721, R01MH059352] Funding Source: NIH RePORTER
  2. NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P01NS040813] Funding Source: NIH RePORTER
  3. NIMH NIH HHS [R01 MH059352-08, R01 MH068721, R01 MH068721-04, MH079621, F32 MH079621, F32 MH079621-01A1, MH059352, MH068721, R01 MH059352] Funding Source: Medline
  4. NINDS NIH HHS [NS40813, P01 NS040813] Funding Source: Medline

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Although the parahippocampal cortex (PHc) is known to be critical for memory formation, little is known about what is encoded by this area. Using multi-voxel pattern analysis of high-resolution functional magnetic resonance imaging (MRI) data, we examined responses to blocks of categorically coherent stimuli and found that patterns of activity in PHc were selective for not only scenes, but also for other non-spatial object categories (e.g., faces and toys). This pattern of results was also found in the parahippocampal place area (PPA), indicating that this region is not sensitive exclusively to scenes. In contrast, neither the hippocampus nor perirhinal cortex (PRc) were found to be selective for category information. The results indicate that regions within the medial temporal lobe may support distinct functions, and that the PHc appears to be particularly sensitive to category-level information. (C) 2008 Wiley-Liss, Inc.

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