Journal
HETEROCYCLIC COMMUNICATIONS
Volume 19, Issue 1, Pages 57-63Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/hc-2012-0053
Keywords
1,8-dioxo-decahydroacridines; heterogeneous catalyst; melamine-formaldehyde; three-component reaction; thiourea
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Funding
- Firoozabad Branch, Islamic Azad University Research Council
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A convenient and practical synthesis of 1,8-dioxo-decahydroacridine derivatives using various aldehydes, 5,5-dimethyl-1,3-cyclohexanedione and thiourea in water, was successfully carried out in the presence of melamine-formaldehyde resin supported H+ (MFRH) as a catalyst. Under solvent-free conditions, rapid and efficient synthesis of 1,8-dioxo-decahydroacridine and N-substituted 1,8-dioxo-decahydroacridine derivatives could also be achieved using ammonium acetate and aromatic amines as the nitrogen source.
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