Journal
HETEROCYCLIC COMMUNICATIONS
Volume 15, Issue 5, Pages 355-360Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/HC.2009.15.5.355
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Funding
- Natural Science Research Plan Projects of Shaanxi Science and Technology Department [SJ08B20]
- Scientific Research Plan Projects of Shaanxi Education Department [08JK413]
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A series of spiro [pyrrolidine-2,3'-oxindole] derivatives were synthesized by 1,3-dipolar cycloaddition reaction of isatin, alpha-amino acid and (E)-beta-substituted-styrene. Four kinds of trapping dipolarophiles were introduced into this reaction, and the regioselectivity of these reactions proved to be the same fashion. Bioactivity screening showed these compounds were active on anti-tumor in A549 and P388 cell line, and several compounds were found to be active under the condensation of 10(-4)M.
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