Journal
HETEROCYCLES
Volume 89, Issue 7, Pages 1662-1669Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-14-13004
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Funding
- Chinese National Natural Science Fund [21102015, 31201034]
- Ministry of Sanitation [WKJ-FJ-14]
- Ministry of Education in Fujian Province [WKJ-FJ-14]
- Natural Science Foundation of Fujian Province [2012J05138]
- Department of Science and Technology in Fujian Province [2012Y0017]
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Four novel tetracyclic oxindole alkaloids, namely, speradines B (1), C (2), D (3), and E (4) were isolated from the marine-derived fungus Aspergillus oryzae. The structures of these compounds without the absolute configurations were elucidated through 1D and 2D nuclear magnetic resonance and high-resolution mass spectrometric analyses. Among these compounds, 1 and 4 showed weak cytotoxic effects on the He La cell line.
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