Journal
HETEROCYCLES
Volume 89, Issue 1, Pages 189-196Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-13-12874
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Funding
- Chinese National Natural Science Fund [21102015, 31201034]
- Natural Science Foundation of Fujian Province [2012J05138]
- Scientific Research Foundation in Fuzhou University [2009-XY-16, 022229]
- Scientific Key Research Project of Fujian Province [2010N0015]
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Three new compounds, trichoderiol C (1), citrinoviric acid (4), and penicillenol D (5), together with seven known compounds, trichoderiol A (2), lignoren (3), penicillenol B-1 (6), penicillenol B-2 (7), cyclo-(Leu-Pro) (8), cyclo-(Ile-Pro) (9), and cyclo-(Phe-Pro) (10), were isolated from the marine-derived fungus Trichoderma citrinoviride. The structures of these compounds were elucidated using spectroscopic methods, including ID and 2D nuclear magnetic resonance and high-resolution mass spectrometric analyses. Among these compounds, 4 and 5 showed moderate cytotoxic effects on the A-375 cell line, with IC50 values of 85.7 and 32.6 mu M, respectively.
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