Journal
HETEROCYCLES
Volume 87, Issue 4, Pages 815-+Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-12-12661
Keywords
Indolizine; Pyrido[1,2-a]benzimidazole; Pyrazolo[1,5-a]pyridine; Arylphosphonate
Categories
Funding
- Science and Technology Special Major Project for Significant New Drugs Formulation [2011ZX09401-009]
- Shandong Natural Science Foundation [Y2008B40]
- Natural Science Foundation of Shandong Province [ZR2012BL04]
Ask authors/readers for more resources
A novel and efficient method was developed for the synthesis of nitrogen bridgehead heterocycles with phosphonates. Nitrogen containing five-membered heterocyclic aldehyde and diethyl 3-bromoprop-1-enylphosphonate were used as substrates. Bridgehead nitrogen-containing arylphosphonates were obtained via one-pot reaction including four steps: S(N)2, deprotonation followed by electron flow, nucleophic additon and elimination of water.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available