Journal
HETEROCYCLES
Volume 85, Issue 6, Pages 1255-1298Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/REV-12-730
Keywords
Total Synthesis; Oxa-Conjugate Addition; Oxa-Michael Addition; Tetrahydropyran; Macrolide
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Funding
- Japan Society for Promotion of Science (JSPS)
- Grants-in-Aid for Scientific Research [24102507, 23681045] Funding Source: KAKEN
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A growing number of tetrahydropyran-containing biologically active substances are being discovered from nature. Intramolecular oxa-conjugate cyclization (IOCC) is known as one of the most powerful methodologies for the stereoselective synthesis of substituted tetrahydropyran derivatives, although there is clearly room for methodological improvement. In this review, we describe our successful total synthesis of tetrahydropyran-containing natural products by exploiting IOCC and the discoveries that we have made during the course of the synthetic campaigns.
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