Journal
HETEROCYCLES
Volume 85, Issue 3, Pages 587-613Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/REV-12-727
Keywords
Aspergillide; Macrolide; Tetrahydropyran; Oxa-Michael Addition; Marine Natural Product
Categories
Funding
- Grants-in-Aid for Scientific Research [22380064, 10J05127] Funding Source: KAKEN
Ask authors/readers for more resources
Aspergillides A, B, and C are cytotoxic macrolides produced by the marine-derived fungus Aspergillus ostiunus strain TUF 01F313. The unique molecular architectures of the aspergillides featuring 14-membered marocyclic structures embedded with a tetrahydro- or dihydropyran unit have attracted significant attention from the synthetic chemistry community, and thereby various synthetic approaches to these structurally as well as pharmacologically intriguing molecules have been reported by as many as 12 research groups in the past 3 years. This review describes all of the syntheses disclosed to date, focusing mainly on the methodologies employed for the diastereoselective installation of the pyran ring systems.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available