Journal
HETEROCYCLES
Volume 85, Issue 7, Pages 1629-+Publisher
Japan Inst Heterocyclic Chemistry
DOI: 10.3987/COM-12-12494
Keywords
Catalyst Free; One-Pot Synthesis; Environmental-Friendly conditions
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Funding
- Department of Chemistry, IIT Roorkee through MHRD, New Delhi
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An efficient one-pot, three-component synthesis method of highly functionalized coumarin fused 7,13-dihydro-5-oxa-13-aza-indeno[2,1-b]phenanthrene and chromeno[4,3-b]quinoline derivatives was accomplished using aromatic aldehyde, 4-aminocoumarin and cyclic 1,3-dione in acetic acid at reflux temperature. Environmental-friendly protocol has advantages of high yields, creating three new bonds and one stereocenter in single operation. Further, XRD and DFT study confirmed the molecular structure, stability and different interaction in the crystal packing.
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