Journal
HETEROCYCLES
Volume 81, Issue 9, Pages 2143-2148Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-10-12005
Keywords
Aspergillus novofumigatus; Novofumigatamide; Fungus; Cyclic Tripeptide
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan [20590017]
- Japan Society for the Promotion of Science
- Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University [09-2]
- Grants-in-Aid for Scientific Research [20590017] Funding Source: KAKEN
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A new cyclic tripeptide, novofumigatamide (1) has been isolated from Aspergillus novofumigatus CBS117520. The relative structure of I was established on the basis of spectroscopic and physico-chemical data and chemical investigations. The absolute structure of 1 was determined by using a Marfey's method. Compound I showed non-specific antifungal activities against some human pathogenic fungi and did not inhibit cell proliferation for any tumor cells.
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