Journal
HETEROCYCLES
Volume 81, Issue 2, Pages 441-450Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-09-11870
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Open Research Center Project
- Faculty of Pharmacy, Airlang-a University
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A new Cephalotaxus alkaloid, cephastigiamide A (1), has been isolated from the leaves of Cephalotaxus harringtonia forma fastigiata and the structure was elucidated by 2D NMR analysis and chemical degradation. Harringtonine, deoxyharringtonine., and homodeoxyharringtonine showed pronounced antiplasmodial activity against Plasmodium falciparum 3D7 but not against Leishmania major. Structure-activity relationship for antiplasmodial activity of isolated Cephalotaxus alkaloids was also discussed.
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