Journal
HETEROCYCLES
Volume 81, Issue 5, Pages 1093-1140Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/REV-09-665
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This review summarizes a variety of synthetic methods for nitrogen heterocycles based on hydrogen transfer reactions catalyzed by transition metals in a past decade. Most of them employ iridium and ruthenium complexes as the catalysts and provide a versatile and environmentally benign synthetic methodology of various nitrogen heterocyclic compounds. Intermolecular cyclization reactions of amines with alcohols afford 5-7 membered alicyclic amines, quinolines, piperazines, indoles, quinoxalines, pyrroles, benzimidazoles, and benzoxazoles. Intramolecular cyclization reactions of amino alcohols give indoles, 1,2,3,4-tetrahydroqunolines, I,2,3,4-tetrahydroquinoxalines, 3,4-dihydro-2(1H)-quinolinones, and oxindoles. Friedlander-type cyclization reactions provide a convenient route to various quinolines. Finally, cyclization reactions of amines with amines afford quinolines and phenylpyrrolidines.
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