Journal
HETEROCYCLES
Volume 80, Issue 1, Pages 281-288Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-09-S(S)11
Keywords
M10709; Streptomyces species; Clinical Isolate; Cyclic Peptide; Antibacterial
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A new cyclic heptapeptide, M10709, was isolated from the mycelial cake of a clinically isolated Streptomyces sp. IFM 10709. The planar structure of M10709 was determined on the basis of IR, MS, NMR, and UV spectra. The absolute configuration of alpha-position of amino acid residues in the acid hydrolysate was determined by advanced Marfey's method to be L except that of tryptophan-derived amino acid. The compound showed antibacterial activity against Micrococcus luteus IFM 2066.
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