Journal
HETEROCYCLES
Volume 78, Issue 7, Pages 1831-1836Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-09-11680
Keywords
Cassiarin A; Cassia siamea; Antimalarial Activity; Plasmodium falciparum
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Funding
- The National Agency of Food and Drug Control of Indonesia
- Assessment Service Unit
- Faculty of Pharmacy, Airlangga University
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Open Research Center Project.
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The extracts and cassiarin A from the leaves of Cassia siamea showed promising antimalarial activities. The ethanol and chloroform extracts, alkaloid fraction, cassiarin A, and chloroquine as a positive control exhibited the inhibition against Plasmodium falciparum (IC50: 7.06, 2.41, 0.24, 0.005, and 0.006 mu g/mL, respectively). The in vivo antimalarial activity was assessed using the 4-day suppressive test procedure. The ethanol, chloroform extracts, and alkaloid fraction were found to give an ED50 34.7, 19.59, and 0.47 mg/kg, respectively (p.o.). The ED50 values of cassiarin A and chloroquine were 0.17 and 0.21 mg/kg, respectively (i.p.). The result showed that cassiarin A deserved further investigation toward development of a promising antimalarial drug.
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