Organotin(IV) esters of (E)-3-furanyl-2-p phenyl-2-propenoic acid: Synthesis, investigation of the coordination modes by IR, multinuclear NMR (H-1,C-13,Sn-119) and in vitro biological studies

Complexes [Me2SnL2 (I), Me3SnL (II) Et2SnL2 (III), n-BU2SnL2 (IV), n-Bu3SnL (V), n-Oct(2)SnL(2) (VI)], where L is (E)-3-furanyl-2-phenyl-2-propenoate, have been synthesized and structurally characterized by vibrational and NMR (H-1, 13 C and Sn-119) spectroscopic techniques in combination with mass spectrometric and elemental analyses. The IR data indicate that in both the di- and triorganotin(W) carboxylates the ligand moiety COO acts as a bidentate group in the solid state. The Sn-119 NMR spectroscopic data, (1)J[Sn-119,C-13] and (2)J[Sn-119, H-1], coupling constants show a coordinated environment around the tin atom, in triorganotin(IV) and five-coordinated in diorganotin (IV) carboxylates in noncoordinating solvents. The complexes have been screened against bacteria, fungi, and brine-shrimp larvae to assess their biological activity. (C) 2008 Wiley Periodicals, Inc.