Journal
HERZ
Volume 33, Issue 2, Pages 88-100Publisher
URBAN & VOGEL
DOI: 10.1007/s00059-008-3101-9
Keywords
myocardial infarction; reperfusion injury; ischemic preconditioning; ischemic post-conditioning
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One or several short cycles of ischemia/reperfusion before (preconditioning) or after (postconditioning) a sustained coronary occlusion with subsequent reperfusion reduce the ultimate infarct size. The protection is potent, but limited to a narrow time frame. In animal experiments, a complex signal transduction cascade was identified which results specifically in a reduction of reperfusion injury. There is evidence for both ischemic pre- and postconditioning in patients with coronary artery disease.
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