Journal
HEREDITY
Volume 114, Issue 5, Pages 431-440Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/hdy.2014.86
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Funding
- Austrian Science Funds (FWF) [W1225]
- ERC (ArchAdapt)
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Evolve and resequence (E&R) is a new approach to investigate the genomic responses to selection during experimental evolution. By using whole genome sequencing of pools of individuals (Pool-Seq), this method can identify selected variants in controlled and replicable experimental settings. Reviewing the current state of the field, we show that E&R can be powerful enough to identify causative genes and possibly even single-nucleotide polymorphisms. We also discuss how the experimental design and the complexity of the trait could result in a large number of false positive candidates. We suggest experimental and analytical strategies to maximize the power of E&R to uncover the genotype-phenotype link and serve as an important research tool for a broad range of evolutionary questions.
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