Journal
HEREDITY
Volume 108, Issue 6, Pages 626-632Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/hdy.2011.133
Keywords
Arabidopsis thaliana; statistical power; QTL detection; multi-parental RILs
Categories
Funding
- Max Planck Society
Ask authors/readers for more resources
A major goal of today's biology is to understand the genetic basis of quantitative traits. This can be achieved by statistical methods that evaluate the association between molecular marker variation and phenotypic variation in different types of mapping populations. The objective of this work was to evaluate the statistical power of quantitative trait loci (QTL) detection of various multi-parental mating designs, as well as to assess the reasons for the observed differences. Our study was based on an empirical data of 20 Arabidopsis thaliana accessions, which have been selected to capture the maximum genetic diversity. The examined mating designs differed strongly with respect to the statistical power to detect QTL. We observed the highest power to detect QTL for the diallel cross with random mating design. The results of our study suggested that performing sibling mating within subpopulations of joint-linkage mapping populations has the potential to considerably increase the power for QTL detection. Our results, however, revealed that using designs in which more than two parental alleles segregate in each subpopulation increases the power even more. Heredity (2012) 108, 626-632; doi:10.1038/hdy.2011.133; published online 15 February 2012
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available