Journal
LANCET ONCOLOGY
Volume 16, Issue 16, Pages E595-E603Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S1470-2045(15)00166-7
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Funding
- Monteris Medical
- Novartis
- Novocure
- Tracon
- Spectrum Pharmaceuticals
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The SPine response assessment In Neuro-Oncology (SPINO) group is a committee of the Response Assessment in Neuro-Oncology working group and comprises a panel of international experts in spine stereotactic body radiotherapy (SBRT). Here, we present the group's first report on the challenges in standardising imaging-based assessment of local control and pain for spinal metastases. We review current imaging modalities used in SBRT treatment planning and tumour assessment and review the criteria for pain and local control in registered clinical trials specific to spine SBRT. We summarise the results of an international survey of the panel to establish the range of current practices in assessing tumour response to spine SBRT. The ultimate goal of the SPINO group is to report consensus criteria for tumour imaging, clinical assessment, and symptom-based response criteria to help standardise future clinical trials.
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