Journal
HEPATOLOGY RESEARCH
Volume 41, Issue 12, Pages 1153-1168Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1872-034X.2011.00878.x
Keywords
Core; double filtration plasmapheresis; hepatitis C virus; IL28B; natural killer cells; T cells
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Funding
- Ministry of Education, Culture, Sport, Science, and Technology of Japan [23790761]
- Ministry of Health, Labor, and Welfare of Japan
- Grants-in-Aid for Scientific Research [23790761] Funding Source: KAKEN
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Aim: The extracellular hepatitis C virus (HCV)-antigen, including HCV-Core protein, can suppress immune cells. Recently, the efficacy of double filtration plasmapheresis (DFPP) for chronic hepatitis C (CHC) was reported. However, the mechanism of efficacy of DFPP might not be only the reduction of HCV but also the effect of immune cells via direct and/or indirect mechanisms. The aim of this study is to analyze the virological and immunological parameters of difficult-to-treat HCV patients treated with DFPP combined with Peg-interferon and RBV (DFPP/Peg-IFN/RBV) therapy.
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