Journal
HEPATOLOGY INTERNATIONAL
Volume 6, Issue 1, Pages 379-385Publisher
SPRINGER
DOI: 10.1007/s12072-011-9277-8
Keywords
Autoantibodies; NASH; NAFLD; Liver histology
Categories
Funding
- National Institute of Diabetes & Digestive & Kidney Diseases
- National Institute of Child health and Human Development
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [U01DK061718, U01DK061728, U01DK061731, U01DK061732, U01DK061734, U01DK061737, U01DK061738, U01DK061730, U01DK061713]
- National Institute of Child Health and Human Development (NICHD)
- General Clinical Research Centres
- NASH CRN Studies [UL1RR024989, M01RR000750, M01RR00188, UL1RR02413101, M01RR000827, UL1RR02501401, M01RR000065, M01RR020359, DK-02957-KK]
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000065, UL1RR024989, M01RR000188, M01RR020359, M01RR000750, M01RR000827] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [U01DK061731, U01DK061718, U01DK061738, K24DK002957, K24DK069290, U01DK061737, U01DK061732, K08DK102957, U01DK061713, U01DK061730, U01DK061728, U01DK061734] Funding Source: NIH RePORTER
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Purpose Some studies have suggested that autoantibodies might define a subcategory and phenotype of nonalcoholic fatty liver disease (NAFLD) associated with advanced histological features. We evaluated the relationship between the presence of serum autoantibodies and liver histology in a large cohort of well-characterized patients with NAFLD. Methods A total of 864 NAFLD patients participating in two prospective multicentre clinical studies underwent testing for serum autoantibodies within 24 months of a liver biopsy. Liver histology was compared between the patients with and without ANA C 1: 160 or ASMA C 1: 40 or both. Results Autoantibodies were present in 182 patients (21%). There was no difference in age, gender, race, body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR), or history of diabetes between the two groups. Biopsies in subjects with autoantibodies were less likely to have moderate-to-severe steatosis (i.e., [33%) compared to controls (57.1 vs. 43.0%, P value = 0.0006). Lobular inflammation (46.7 vs. 47.5%), ballooning degeneration (38.5 vs. 42.5%), and advanced fibrosis (33.2 vs. 29.3%) were not different between the two groups. Histologic evidence of 'definite' NASH did not differ significantly between the two groups (55.5 vs. 58.9%). After adjusting for age, gender, BMI, race, and diabetes, the presence of autoantibodies was independently associated with lower prevalence of moderate-to-severe steatosis [odds ratio (OR), 0.58; 95% confidence interval (CI), 0.41-0.82; P = 0.01]. Conclusion Autoantibodies are frequently positive in NAFLD in the absence of autoimmune hepatitis and their occurrence is not associated with more advanced histologic features.
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